Many older diabetes medications do cause weight gain. Included in this are widely prescribed sulfonylureas, more commonly known as Diabinese (chlorpropamide), Amaryl (glimepiride), Glucotrol (glipizide), and DiaBeta, Glynase, and Micronase (glyburides). Prandin (repaglinide) and Starlix (nateglinide) also cause weight gain.
All these medications stimulate the beta cells in the pancreas to create more insulin to control blood sugar levels. Hypoglycemia (low blood sugar) and putting on weight are the two most frequently reported unwanted effects of these drugs: Hypoglycemia makes you consume extra carbohydrates to raise your glucose, also it stimulates appetite.
Thiazolidinediones, more often called Actos (pioglitazone) and Avandia® (rosiglitazone), promote putting on weight by triggering an enzyme that causes fat cells to enlarge by storing more fatty acids. Thiazolidinediones may also cause fluid retention, which increases bodyweight. Research has shown that the gain is generally not more than five or six pounds.
By comparison, Glucophage, the brand name for metformin, has been shown in studies not to cause putting on weight; it may even help manage weight or result in a small weight reduction, normally four to six pounds. Metformin helps curb hunger by preventing the liver from producing extra, unneeded blood sugar, and it doesn't cause hypoglycemia.
Adding Glucophage to your regimen and reducing another oral medication may help limit putting on weight. Januvia, a more recent oral medication, is weight neutral, and most patients think it is easy to tolerate. Insulin could also cause weight gain - but not for the reason you think - and a newer class of medication cause weight loss.
Sudden putting on weight from fluid retention could be a side effect of an oral diabetes medication, however it may also be a symptom of the number of serious underlying medical problems, including heart disease, kidney disease, hypertension, as well as irritable bowel syndrome or celiac disease. Discuss any sudden, unexplained, or significant weight loss or gain with your health care provider.
Byetta, the first in a brand new class of medication called incretin mimetics (drugs that mimic the result of certain gut hormones), improves the body's ability to manage blood sugar levels by stimulating insulin production; inhibiting the liver from secreting glucagon, a hormone involved in carbohydrate metabolism; and slowing stomach emptying, which makes you full faster. Byetta continues to be turned out to be result in significant weight loss in patients.
In clinical trials, people using Byetta lost an average of 6.6 pounds after thirty weeks and 10.66 pounds after eighty-two weeks. Byetta, a synthetic form of a hormone that occurs naturally in the saliva of the Gila monster - a large venomous lizard native to the southwestern Usa and Mexico - is injectable and it is usually prescribed together with metformin along with a sulfonylurea or a thiazolidinedione when patients are not achieving glucose targets with pills alone.
Byetta has fewer unwanted effects than many oral agents; however, most people do experience some nausea in the first couple weeks. "I've had a lot of patients lose weight on Byetta®," a diabetes educator told me, "that I'd put most of my patients on it if they weren't afraid of taking injections." Byetta is only used for type 2 diabetes.
Symlin is a synthetic type of another hormone called amylin, which is secreted by beta cells after meals to help turn off one's appetite and level out post-meal glucose peaks. Symylin helps patients lose weight by decreasing their appetite and slowing the rate at which food passes in the stomach to the intestines.
Research published in Medicine Plus: Journal of Clinical Endocrinology and Metabolism in August 2007 showed that among 102 patients with a body mass index (BMI) of 37.8 (a person with a BMI over 30 is classified as obese) who participated in a sixteen-week trial using Symlin, 31 percent lost 5 percent or more of the total bodyweight, or roughly eight pounds and one and one-half inches using their waistlines. What's more, 72 percent of the patients said their appetite control had improved. Symlin is definitely an injectable drug and may help anyone who uses insulin.
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