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Science and Reference Articles

The hypothalamus and other neuronal markers - ...he anterior pituitary gland and the brain, two known sites of GHS action. It will be of considerable interest to map the tissue distribution of GHS-R ...
Functional activation of cloned cells - ...r human embryonic kidney fibroblasts (HEK-293). Both cell types do not express detectable endogenous GHS-Rs. Binding and functional activation assays ...
Clinical evaluation in humans - ...e second phase, we concentrated on the isolation of GHS-R related sequences from lower vertebrates. Interestingly, GHS-R related sequences were indeed...
Regulation of synthesis and secretion - ...P receptor in several animal species including man. In spite of the efficacy and relative specificity of GHRPs for the stimulation of GH release, and ...
Measurement of intracellular calcium - ...lated rat somatotrophs, GHRP-6 evoked dual-phase increases in Ca; an initial transient increase due to intracellular Ca release and a second longer la...
Significant species difference exists between sheep and rat - ...ntracellular cAMP levels. Similar results are also found for the non-peptidergic analogue L-692,429, but synergy could not be demonstrated with GHRP-1...
Identical effects on hydrolysis and secretion - ...e GH-secretagogue receptor (GHS-R) mRNA has also been described in human adenomatous and fetal pituitary tissue as well as in ectopic endocrine tumour...
Positive effect on human adenoma cells - ...er preliminary report. The effect observed on ACTH release was actually greater than that seen after CRH stimulation on cells derived from the same ad...
Possible changes in the activity of arcuate neurones - ...sm that includes effects on the hypothalamic GHRH-somatostatin pulse generating system. In the 1980s CY. Bowers and colleagues identified the first me...
Neurones are neuroendocrine cells - ...ne cells (e.g. the tuberoinfundibular dopamine neurones) and many non-neuroendocrine cells. Thus, it was first necessary to determine whether the cell...
Acute effects on feeding behaviour - ...trations which are higher than in the peripheral circulation it is not clear whether the arcuate NPY cells are true neurosecretory adenohypophysiotrop...
A model of pituitary desensitization - ...ntal procedure, and animal specie. However, GHRP-6 was found more efficient in primates than in rat, dog or farm animals. Walker et al. demonstrated t...
Enhancement of hormone release - ...xarelin injection; SRIH levels in HPB did not change throughout the study; the magnitude of GHRH increase after acute hexarelin administration was sim...
Growth hormone secretion is pulsatile in mammals - ...lsatile GH. Similar results were obtained in human. Number, duration and height of GH pulses, incremental pulse amplitude, interpeak valley concentrat...
Change in the extracellular portion of the receptor - ...portance is underscored by the fact that for many, human counterparts have been identified that are associated with clinical disorders of impaired GH ...
Fluctuations are organized into pulses - ... organized into discrete secretory pulses and long periods of secretory quiescence. Alterations in GH pulsatility are seen in a variety of physiologic...
Hormonal therapy in obesity - ...H secretion is enhanced during fasting, in obese individuals, spontaneous GH secretion is attenuated and the GH response to all tested stimuli (hypogl...
Building automated systems in aircrafts - ...d the demanding situations. If we talk about vehicle guidance and control with control engineers, they may look at the same thing from a different per...
Concept of operation in military high performance aircraft - ...the mechanical linkages, causing the control stick to move according to the nested outer and inner loop commands of the autopilot. Today, autopilots m...
Automatic systems for guidance and control in automotive vehicles - ...he first and only automatic support for the driver for a long time was the automatic gear. Later, in addition to that the function of cruise control c...
Talking about the concept of work and its implications - ... order to make use of it for the enhancement of vehicle guidance and control. In essence, this leads to an understanding of two general concepts, that...
The operating force is the most important component of the work system - ...t the highest authority level. It is only this component where the complete knowledge about the work objective is placed as well as the knowledge need...
The basic work site settings are not part of the productive work process - ...workshop tool and other tool box items, bicycles as vehicles and others. All powered tools belong to the category of machines. For the work objective ...
What is engineering of work system development - ...ovide the best prospect of cost reduction in whatever sense, e.g. economic gain, safety enhancement, more convenience for the human operator(s), and s...
A few essential concepts about human cognition - ...sses there is a human operator who represents the highest operating authority. The human's prominent role of being the highest authority in the work p...
How to understand the implementation principles of human cognition - ...-optimality concerning our performance in modern times. The slow pace of natural evolution lets us assume that the human race of today mirrors the pre...
Distinctive brain areas and the cognitive functions - ... surgical operations and trials with animals, that cognition is established by the interplay of distinctive neural network structures which, depending...
How to understand the principles of human memory - ... heavily on the recency of the information presented or how often it has been repeatedly experienced. The more refreshment is happening by repetitions...
Human cognition and the two modes of information processing - ...s capacity can hardly be exhausted, but the processing lacks flexibility because of fixed, stored processing patterns (automatisms) and is therefore u...
What do researchers know about the working memory - ...tal cortex. The content of the working memory changes in a serial manner. Only a single entry of the working memory can be processed at a time. This w...
How to understand the limbic system - ...ational contexts. It more or less dictates the first cognitive reaction, and after loop-like activations sweeping through numbers of brain structures,...
A few characteristics of the work system designer - ...work process based on the knowledge about the strengths and weaknesses in human cognition, • to generate models of human behaviour which ...
The three functional levels of human cognition - ...uainted with them to a sufficient extent that we can exploit it for work system design. For this purpose, this article will sum up by suggesting in th...

Latest "Philosophy" Articles


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The Human Mind (01/17/2010)
(...) It consists of an impossible task, discuss with an advantage over different types of mind without referring to the various factors that come to form the different types of human beings. Psychologists used to think that the spirit was, simply, brain function, just as the bile is a product of the liver and the breathing function of the lungs. We now know that it requires much more than two lungs for breathing (also a nose, trachea, some chest muscles, diaphragm and a regulating center). (...)
PSYCHOLOGICAL ATTACKS ON GAY SEXUAL CULTURE (11/15/2008)
(...) Some gay men found that their profound anxiety and fears sometimes interfered with their ability to adopt low-risk sexual practices. Some even discussed in therapy sessions how nerve-wracking it was for them not to be able to reduce their number of sexual partners or adopt safer sex precautions, even while knowing that it was precisely the sexual nature of HIV transmission that made them afraid and anxious. When talk therapy alone did not help, a referral to a psychopharmacologist for a prescription of antianxiety or antidepression medication sometimes was appropriate. (...)
Scepticism in Modern Philosophy (05/17/2008)
(...) than to catch philosophers of this kind by the words they speak’. It is Descartes (1596–1650), however, who is generally considered to be the figure who brings scepticism most fully into the modern philosophical world, in his quest to find a secure basis for a theory of knowledge. He subjected all his beliefs to scrutiny, seeking to locate that elusive starting point from which he could then build outwards with assurance. (...)
Scepticism in Islamic Philosophy (05/17/2008)
(...) From our point of view it is unfortunate that Al-Ghazali’s scepticism ultimately was overcome by his religious belief. Whereas for Pyrrhonians dogmatism was the ‘disease’ to be feared, for Al-Ghazali that was scepticism. He speaks of God having ‘cured me of this malady’ in his autobiographical work Deliverance from Error (c. (...)
Scepticism in Contemporary Philosophy (05/17/2008)
(...) The attempt to meet, or even to understand, the sceptical challenge to our knowledge of the world is regarded in some circles as an idle academic exercise, a wilful refusal to abandon outmoded forms of thinking in this new post-Cartesian age. Stroud, as we shall see below, strongly disagrees with this negative assessment. Yet the anti-sceptical impulse is nevertheless commendable enough in its way, being concerned to prevent philosophy from collapsing into arguments about the grounds for argument, in which case the subject is not addressing all the other problems in the world around us – problems of ethics and politics, for example. (...)
Classical Scepticism (05/15/2008)
(...) they still provide the subject of epistemology with some of its most cunning puzzles and most obdurate problems’.5 Pyrrhonism is to be considered, therefore, more than just a historical curiosity. It provides an extremely useful point of reference for rethinking the project of scepticism in the twenty-first century. (...)

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