Science and Reference Articles
Development of absorbable peptides
- ...e discoverer of the original GHRP series has reviewed their history. Other excellent reviews of this new class of GH Secretagogues have been published...
Molecules with specific activity
- ...e of other hormones, especially ACTH and prolactin. However in terms of in vivo activity it is clear that the GHRPs do release ACTH and prolactin in t...
Effects on efficacy endpoints
- ...en after several hours a long-term down-regulation of GH secretion. We have published the only comparison of different patterns of GHRP exposure on lo...
Functional activation of cloned cells
- ...r human embryonic kidney fibroblasts (HEK-293). Both cell types do not express detectable endogenous GHS-Rs. Binding and functional activation assays ...
Clinical evaluation in humans
- ...e second phase, we concentrated on the isolation of GHS-R related sequences from lower vertebrates. Interestingly, GHS-R related sequences were indeed...
Regulation of synthesis and secretion
- ...P receptor in several animal species including man. In spite of the efficacy and relative specificity of GHRPs for the stimulation of GH release, and ...
Measurement of intracellular calcium
- ...lated rat somatotrophs, GHRP-6 evoked dual-phase increases in Ca; an initial transient increase due to intracellular Ca release and a second longer la...
Positive effect on human adenoma cells
- ...er preliminary report. The effect observed on ACTH release was actually greater than that seen after CRH stimulation on cells derived from the same ad...
Neurones are neuroendocrine cells
- ...ne cells (e.g. the tuberoinfundibular dopamine neurones) and many non-neuroendocrine cells. Thus, it was first necessary to determine whether the cell...
Acute effects on feeding behaviour
- ...trations which are higher than in the peripheral circulation it is not clear whether the arcuate NPY cells are true neurosecretory adenohypophysiotrop...
A model of pituitary desensitization
- ...ntal procedure, and animal specie. However, GHRP-6 was found more efficient in primates than in rat, dog or farm animals. Walker et al. demonstrated t...
Enhancement of hormone release
- ...xarelin injection; SRIH levels in HPB did not change throughout the study; the magnitude of GHRH increase after acute hexarelin administration was sim...
Fluctuations are organized into pulses
- ... organized into discrete secretory pulses and long periods of secretory quiescence. Alterations in GH pulsatility are seen in a variety of physiologic...
Hormonal therapy in obesity
- ...H secretion is enhanced during fasting, in obese individuals, spontaneous GH secretion is attenuated and the GH response to all tested stimuli (hypogl...
Building automated systems in aircrafts
- ...d the demanding situations. If we talk about vehicle guidance and control with control engineers, they may look at the same thing from a different per...
Latest "Philosophy" Articles
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The Human Mind
It consists of an impossible task, discuss with an advantage over different types of mind without referring to the various factors that come to form the different types of human beings. Psychologists used to think that the spirit was, simply, brain function, just as the bile is a product of the liver and the breathing function of the lungs. We now know that it requires much more than two lungs for breathing (also a nose, trachea, some chest muscles, diaphragm and a regulating center). (...)
PSYCHOLOGICAL ATTACKS ON GAY SEXUAL CULTURE
Some gay men found that their profound anxiety and fears sometimes
interfered with their ability to adopt low-risk sexual practices. Some
even discussed in therapy sessions how nerve-wracking it was for them
not to be able to reduce their number of sexual partners or adopt safer
sex precautions, even while knowing that it was precisely the sexual nature
of HIV transmission that made them afraid and anxious. When
talk therapy alone did not help, a referral to a psychopharmacologist for
a prescription of antianxiety or antidepression medication sometimes
was appropriate. (...)
Scepticism in Modern Philosophy
(...) than to catch philosophers
of this kind by the words they speak’.
It is Descartes (1596–1650), however, who is generally considered
to be the figure who brings scepticism most fully into the modern
philosophical world, in his quest to find a secure basis for a theory
of knowledge. He subjected all his beliefs to scrutiny, seeking to
locate that elusive starting point from which he could then build outwards
with assurance. (...)
Scepticism in Islamic Philosophy
From our point of view it is unfortunate that Al-Ghazali’s scepticism
ultimately was overcome by his religious belief. Whereas for
Pyrrhonians dogmatism was the ‘disease’ to be feared, for Al-Ghazali
that was scepticism. He speaks of God having ‘cured me of this
malady’ in his autobiographical work Deliverance from Error (c. (...)
Scepticism in Contemporary Philosophy
(...) The attempt to meet, or even to understand,
the sceptical challenge to our knowledge of the world is regarded
in some circles as an idle academic exercise, a wilful refusal to abandon
outmoded forms of thinking in this new post-Cartesian age.
Stroud, as we shall see below, strongly disagrees with this negative
assessment. Yet the anti-sceptical impulse is nevertheless commendable
enough in its way, being concerned to prevent philosophy
from collapsing into arguments about the grounds for argument, in
which case the subject is not addressing all the other problems in the
world around us – problems of ethics and politics, for example. (...)
(...) they still provide the subject of epistemology with
some of its most cunning puzzles and most obdurate problems’.5
Pyrrhonism is to be considered, therefore, more than just a historical
curiosity. It provides an extremely useful point of reference
for rethinking the project of scepticism in the twenty-first century. (...)
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